Endocrine Abstracts

Background: Klinefelter syndrome (KS) is associated with increased risk of psychiatric disease and behavioral problems, as well as social problems. The background for these risks is not known.Aim: The aim was to describe the cognitive function, personality traits and the vulnerability to psychiatric symptoms in patients with KS.Methods: Fourty one KS patients and 41 age- and educational-matched control subjects participated in the ...

Aims/hypothesis: Circulating erythropoietin (EPO) and vascular endothelial growth factor (VEGF) increase during hypoglycaemia and may represent a protective hormonal counter-regulatory response. We tested the hypothesis that low levels of EPO and VEGF are associated with a higher frequency of severe hypoglycaemia in a cohort of patients with type 1 diabetes.Methods: Two hundred and nineteen patients with type 1 diabetes (41% females, age 46±13 years...

Adrenal insufficiency can result in severe hyponatremia due to inappropriate high plasma vasopressin (pAVP). To elucidate the glucocorticoid AVP feedback we monitored thirsting of 12 male volunteers without and after on or five days of prednisolone (30 mg/d). Although prednisolone suppressed pAVP below 0.2 pg/ml the rise in plasma osmolality during thirsting was not influenced by prednisolone. Independent of exogenous glucocorticoid thirsting resulted in higher urine osmolalit...

Aim: To evaluate the quality of diabetes group-based education followed by shared care. The diabetes education programme had a duration of 4 days and included screening for diabetes late complications. Patients with microvascular complications should visit the diabetes clinic four times a year. Patients without microvascular complications should visit their general practitioner every third month and the diabetes clinic once a year.Methods: Retrospective ...

Both humic substances (HS) and iodine may influence the thyroid gland. Tap water is a major source of iodine intake in some areas, where iodine has been shown to be bound in HS.We investigated tap water and old subjects from two areas with and without iodine bound in HS in tap water, to assess their importance for urinary iodine excretion and for the thyroid. Analysis of tap water, measurement of iodine in urine and thyrotropin (TSH), thyroid peroxidase ...

Objectives: Iodine fortification (IF) induces an initial increase followed by a decrease in the incidence of hyperthyroidism in the population. Also, the sex-, age-, and subtype distribution of hyperthyroid cases changes after IF. The risk of atrial fibrillation (AF) in hyperthyroid patients is influenced by these factors. Therefore, we aimed to examine how the association between incident hyperthyroidism and atrial fibrillation was affected by an IF increasing the population ...

Background: GH potently stimulates collagen turnover which underlies its anabolic effects on bone in children, whereas it may promote fibrosis in adults. Fibroblast activation protein-α (FAPα) is involved in collagen turnover by its collagen-cleaving and fibroblast-stimulating activity, which predominantly is expressed in association with fibrosis. FAPα also cleaves and inactivates fibroblast growth factor 21 (FGF21), a multi-faceted metabolic hormone. We have p...

Background: Few studies have scrutinized the spectrum of symptoms in subclinical hypothyroidism.Methods: From three DanThyr cross-sectional surveys performed in the period 1997 to 2005, a total of 8,903 volunteers participated in a comprehensive investigation including blood samples and questionnaires on previous diseases, smoking habits, alcohol intake, and education. From the three surveys we included patients with unknown subclinical hypothyroidism (<...

Background: It is well-known that growth hormone (GH) potently stimulates collagen turnover and it is associated with fibrosis in several tissues, but the mechanisms involved in GH-stimulated fibrosis are poorly elucidated. Fibroblast activation protein-α (FAPα) is an enzyme that can cleave collagens and is expressed almost only under pathological conditions such as fibrosis. FAPα also cleaves and inactivates fibroblast growth factor 21 (FGF21), which is a circu...

Background: Subclinical hypothyroidism is associated with a number of cardiovascular risk factors such as hypertension, hypercholesterolemia, and diastolic dysfunction, but only limited data exist on long-term outcome of levothyroxine substitution therapy.Objectives: To examine effects of levothyroxine substitution treatment on mortality in patients with subclinical hypothyroidism.Study design: Historical cohort study.<p class=...